Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures
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Gurkan, U. A., Fan, Y., Xu, F., Erkmen, B., Urkac, E. S., Parlakgul, G., Bernstein, J., Xing, W.*, Boyden, E. S.*, Demirci, U.* (2013) Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures, Advanced Materials 25(8):1192-1198. (* co-corresponding authors)
Complex architectures of integrated circuits are achieved through multiple layer photolithography, which has empowered the semiconductor industry. We adapt this philosophy for tissue engineering with a versatile, scalable, and generalizable microfabrication approach to create engineered tissue architectures composed of digitally specifiable building blocks, each with tuned structural, cellular, and compositional features.