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Brian Chow

Brian Chow, during his time in the lab as a postdoctoral fellow, developed new molecular and physical tools to control excitable cells, including genetically targetable, light-activated neural activity silencers. Earlier, he received his Ph.D. from MIT, inventing a platform for optically synthesizing DNA microarrays by leveraging semiconductor photoelectrochemistry. Prior to MIT, Brian received his B.S. Chemistry from Stanford University and worked as an engineer at IBM Storage Systems Division. After finishing his work in the lab, he went on to become an assistant professor at U. Penn.

Projects

Optogenetic hardware and systems for control of neural circuits and biological functions with light
Recording and data analysis technologies for observing and analyzing neural circuit dynamics
Optogenetic molecular reagents enabling control of targeted neurons and biological functions with light

Publications

Chow, B. Y. and Boyden, E. S. (2013) Optogenetics and Translational Medicine, Science Translational Medicine 5(177):177ps5.
Kodandaramaiah, S., Talei Franzesi, G., Chow, B., Boyden, E. S.*, Forest, C.* (2012) Automated whole-cell patch clamp electrophysiology of neurons in vivo, Nature Methods 9:585–587. (* co-corresponding authors)
Chow B.Y., Han, X., Boyden, E. S. (2012) Genetically encoded molecular tools for light-driven silencing of targeted neurons, Progress in Brain Research 196:49-61.
Joo, J., Chow, B. Y., Prakash, M., Boyden, E. S., Jacobson, J. M. (2011) Face-selective electrostatic control of hydrothermal zinc oxide nanowire synthesis, Nature Materials 10(8):596-601.
Chow, B. Y. and Boyden, E. S. (2011) Synthetic Physiology, Science 332(6037):1508-1509.
Chow, B. Y.*, Chuong, A. S. *, Klapoetke, N. C. *, Boyden, E. S. (2011) Synthetic Physiology: Strategies for Adapting Tools from Nature for Genetically-Targeted Control of Fast Biological Processes, Methods in Enzymology 497:425-43. (* co-first authors)
Han, X.*, Chow, B. Y.*, Zhou, H., Klapoetke, N. C., Chuong, A., Rajimehr, R., Yang, A., Baratta, M. V., Winkle, J., Desimone, R., Boyden, E. S. (2011) A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex, Frontiers in Systems Neuroscience 5:18. (* co-first authors)
Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2011) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons, Chapter 6, Photosensitive Molecules for Controlling Biological Function, edited by James J. Chambers and Richard H. Kramer, Neuromethods Series Volume 55, Humana Press.
Boyden, E. S. and Chow, B. Y. (2010) "Defining An Algorithm For Inventing From Nature." Column, Technology Review. 1/19/2010.
Chow, B. Y.*, Han, X.*, Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., Boyden, E. S. (2010) High-performance genetically targetable optical neural silencing by light- driven proton pumps, Nature 463:98-102. (* co-first authors)

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