Annabelle, as a postdoc in the lab, investigated synaptic and ionic mechanisms in hippocampal neurons and circuits underlying learning and memory in awake behaving mice. To do this, Annabelle and collaborators developed awake autopatching, a new method for performing automated whole cell patch clamp of neurons in awake behaving animals. Additionally, Annabelle investigated how we remember important experiences, using optogenetic tools to manipulate circuitry involved in emotional processing to determine how these circuits alter memory. Annabelle received her Ph.D. from UCSF, performing research in the laboratory of Loren Frank, studying how reward modulates hippocampal memory processes and how this hippocampal activity predicts behavioral performance. She then moved on to a tenure-track faculty job at Georgia Tech.
Iaccarino HF*, Singer AC*, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH (2016) Nature 540(7632):230-235. (*, co-first authors)
Kodandaramaiah, S.B., Holst, G.L., Wickersham, I.R., Singer, A.C., Talei Franzesi, G., McKinnon, M.L., Forest, C.R., Boyden, E.S. (2016) Assembly and operation of the autopatcher for automated intracellular neural recording in vivo, Nature Protocols 11:634–654.